Content (Syllabus outline)
Cell cycle: Progression of cell cycle and cell cycle checkpoints. Cyclin dependent kinases and cyclins regulate the cell cycle. Cell death – apoptosis.
Horizontal DNA transfer in prokaryotes and eukaryotes.
Transposones and their evolution.
Intrones, cellular role and splicing mechanisms.
Characteristics of genomes and organisation of genome structure in bacteria, archaea and of bacteriophages. Characteristics of protein-nucleic acid interactions. Conservation of mechanisms of DNA damage repair in prokaryotes.
Molecular regulatory networks: activation of transcription, global regulators of gene expression, termination of transcription. Mechanisms of genome duplication in prokaryotes. Small bacterial RNA molecules, eukaryotic microRNA molecules.
RNA interference and gene silencing.
Epigenetic mechanisms.
Model organsims in molecular biology, from microorganisms to mammals.
Mechanisms govering the bacteria-bacteriophage interaction.
Prerequisites
Prerequisites for inclusion in the work:
• enrolment in the appropriate academic year
• knowledge of biochemistry and genetics at BSc level.
Prerequisites for performing study obligations:
Practical examination (colloquium):
• presence at practicals
Exam:
• practical examination (colloquium)